|
X-linked agammaglobulinemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study LPS (TLR4) or an imidazoquinoline compound (TLR7/8) activated XLA neutrophil shedding of surface CD62L, and phosphorylated MAP kinases p38, JNK and ERK.
|
20634142 |
2010 |
|
X-linked agammaglobulinemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Herein, we measured TLR-4 and TLR-9 RNA levels and consequently TNF-α and IFN-α production in peripheral blood mononuclear cells (PBMCs) of patients with CVID and XLA.
|
30698158 |
2018 |
|
Wheezing
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis.
|
19773677 |
2009 |
|
Wheezing
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
No association was found between TLR4/Asp299Gly and lung function or wheeze.
|
15591473 |
2005 |
|
Wheat Hypersensitivity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings implicate a causative chain between nitration, enhanced TLR4 stimulation, and adaptive immune responses, providing major implications for public health, as nitrated ATI may strongly promote inhalative wheat allergies (baker's asthma), non-celiac wheat sensitivity (NCWS), other allergies, and autoimmune diseases.
|
30740114 |
2018 |
|
Weight decreased
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether there is an association between TLR 2 and TLR4 gene polymorphisms in Turkish patients with vitiligo.
|
22429552 |
2013 |
|
Vitiligo
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether there is an association between TLR 2 and TLR4 gene polymorphisms in Turkish patients with vitiligo.
|
22429552 |
2013 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings support the conclusion that selective suppression of CXCL1/CXCL2 represents an IFN-β-mediated "training" of the macrophage transcriptional response to TLR2 agonists and that blocking of TLR4 therapeutically with Eritoran after influenza virus infection reverses this suppression by blunting influenza-induced IFN-β.
|
31064834 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings suggest that treatment with the TLR4 agonist Immunomax polarizes the immune response towards antiviral Th1 and may be used for short-term antiviral prophylaxis to prevent acute respiratory viral infections in asthmatics.
|
30713767 |
2020 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The TLR4-TRIF pathway protects against H5N1 influenza virus infection.
|
22031950 |
2012 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Eritoran, a Toll-like receptor 4 (TLR4) antagonist, was previously shown to result in protection of mice against lethal influenza virus infection.
|
28442605 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
TLR3 and TLR4 are involved in the pathogenesis of viral infections.
|
28823914 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, dysregulation of miRNA and mRNA expression was observed in the respiratory tract of H5N1 CIV-infected dogs and notably, TLR4 (miR-146), NF-κB (miR-34c) and CCL5 (miR-335), CCL10 (miR-8908-5p), and GNGT2 (miR-122) were found to play important roles in regulating pathways that resist virus infection.
|
29556219 |
2018 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Thus, the 299/399 TLR4 haplotype has only minor influence on susceptibility and severity of complicated dengue virus infection.
|
21813858 |
2011 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Here we tested the activity of the small-molecule synthetic TLR4 antagonist, FP7, in vitro on human monocytes and monocyte-derived dendritic cells (DCs) and in vivo during influenza virus infection of mice.
|
28106157 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Based on recent data showing that rhesus macaque θ-defensins could inhibit TLR4-dependent gene expression, we tested the hypothesis that a novel θ-defensin, retrocyclin (RC)-101, could disrupt TLR4-dependent signaling and protect against viral infection.
|
28729359 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Understandably, an increased IFN-β level facilitated phosphorylation of STAT1 to induce expression of innate antiviral genes Mx1 and ISG15, suggesting that TLR4 overexpressing macrophages were equipped better against viral infection.
|
30522781 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In the present study, we investigated whether TLR4 triggering could improve PD-1 therapy during a chronic viral infection.
|
30726291 |
2019 |
|
Very Low Birth Weight
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
We determined the -159T mutation of the CD14 gene, the 896G mutation of the toll-like receptor 4 gene, the 3020insC mutation of the NOD2 gene (NOD2-3020insC), the IL-6 174G/C promoter polymorphism (IL6-174G/C), and the mannose-binding lectin genotype and their association to the subsequent development of neonatal sepsis in a large cohort of very low birth weight (VLBW) infants.
|
14739370 |
2004 |
|
Very Low Birth Weight
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Carrier state of the tested CD14, TLR4, and CARD15 SNPs is not associated with NEC risk in VLBW infants.
|
16385250 |
2006 |
|
Vertigo
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Ventricular Dysfunction, Left
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Toll-like receptor 4 ablation rescues against paraquat-triggered myocardial dysfunction: Role of ER stress and apoptosis.
|
27442881 |
2017 |
|
Ventricular arrhythmia
|
0.020 |
Biomarker
|
disease |
BEFREE |
TLR4 knockdown also exhibited a lower arrhythmia score following programmed electrical stimulation than those treated with MI surgery only, indicating that the knockdown of TLR4 decreased the incidence of malignant ventricular arrhythmias following MI.
|
30978539 |
2019 |
|
Ventricular arrhythmia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Loss of MD1 increases vulnerability to ventricular arrhythmia in diet-induced obesity mice via enhanced activation of the TLR4/MyD88/CaMKII signaling pathway.
|
31353205 |
2019 |